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The Moment Channel and Signal Are Blocked at Once (6)

The Dual Blockade That Microcalcification Creates

D
DTDMC Lab
DTDMC Institute
This piece is the latter part of Chapter 8 of Stones in the Body: More Frightening Than Cancer (Yoon Jong-won). It is a narrative that contains the author's academic hypothesis, and the body, figures, and citations follow the manuscript as written.

To the Next Chapter: From Lockdown to Manifestation

Let us confirm once more the position of this chapter.

The DIAH-7M Aging and Chronic Disease Pathway System is composed of five stages.

[Table 13] The Five Stages of the DIAH-7M (DIAH-Seven-M) Pathway System (the position of this chapter)

StageEnglishTheory NameNote
① FactorFactorDIAH Four-Gate Funnel Theory
② StartStartDIAH Trigger Bone Calcium Efflux Theory
③ LockdownLockdownCalcium Absorption and Microcalcification Dual Blockade Theory◀ This chapter
④ ManifestationManifestationCalcification 7M Pathological Manifestation Theory◀ Next chapter
⑤ ResultResult7M Collapse of the Life System

The CAM Dual Blockade (CAM-DLT) treated in this chapter, that is, the Calcium Absorption and Microcalcification Dual Blockade Theory, corresponds to the third of the five stages, namely the domain of ③ Lockdown. We examined how instability in calcium absorption breaks down cell signaling, how microcalcification blocks the channel, how energy production declines, and even how these three blockades reinforce one another.

In the next chapter we look at what actual "disease" this blockade appears as. This is the fourth stage, the domain of ④ Manifestation. When the dual blockade persists, seven forms of pathological change appear in each tissue. 1M Obstruction & Rupture that blocks and bursts, 4M Hardening that hardens, 5M Overflow & Burst that proliferates excessively... Though they begin from the same blockade, depending on which tissue is blocked first, they manifest as diseases of different names.

To summarize, if the Calcium Absorption and Microcalcification Dual Blockade Theory (CAM-DLT) showed "why the cell is blocked (Lockdown)," the Calcification 7M Pathological Manifestation Theory (Ca-7M, Calcium-Seven-M) shows "what disease the blockade appears as (Manifestation)." The pathway that leads from the dual blockade (CAM-DLT) to the seven manifestations (7M), that world of manifestation, will unfold in earnest in the next chapter.

References

1. Peacock M. Calcium metabolism in health and disease. Clinical Journal of the American Society of Nephrology. 2010;5 Suppl 1:S23-S30.

2. Clapham DE. Calcium signaling. Cell. 2007;131(6):1047-1058.

3. Berridge MJ, Bootman MD, Roderick HL. Calcium signalling: dynamics, homeostasis and remodelling. Nature Reviews Molecular Cell Biology. 2003;4(7):517-529.

4. Giorgi C, et al. Calcium signaling as a trigger for cell death. The FEBS Journal. 2008;275:1830-1830.

5. Shanahan CM, Crouthamel MH, Kapustin A, Giachelli CM. Arterial calcification in chronic kidney disease: key roles for calcium and phosphate. Circulation Research. 2011;109(6):697-711.

6. Giachelli CM. Vascular calcification mechanisms. Journal of the American Society of Nephrology. 2004;15(12):2959-2964.

7. Rizzuto R, De Stefani D, Raffaello A, Mammucari C. Mitochondria as sensors and regulators of calcium signalling. Nature Reviews Molecular Cell Biology. 2012;13(9):566-578.

8. Longo M, Zatterale F, Naderi J, et al. Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications. International Journal of Molecular Sciences. 2019;20(9):2358.

9. Creager MA, Lüscher TF, Cosentino F, Beckman JA. Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: Part I. Circulation. 2003;108(12):1527-1532.

10. London GM, Guérin AP, Marchais SJ, et al. Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality. Nephrology Dialysis Transplantation. 2003;18(9):1731-1740.

11. Kapustin AN, Chatrou ML, Drozdov I, et al. Vascular smooth muscle cell calcification is mediated by regulated exosome secretion. Circulation Research. 2015;116(8):1312-1323.

12. Leopold JA. Vascular calcification: Mechanisms of vascular smooth muscle cell calcification. Trends in Cardiovascular Medicine. 2015;25(4):267-274.

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