Continuing from the previous part, we look at calcium and evolution. The cited references follow the manuscript as written.
The Two Faces of Calcium That DIAH-7M Reveals: The Blueprint of Life and the Blueprint of Collapse
Within the DIAH-7M system, calcium has two faces. One is its face as the "blueprint that builds life," and the other is its face as the "blueprint of collapse that dismantles life." The same substance performs completely opposite roles depending on the situation.
On the side that builds life, calcium is deeply involved in cell division and differentiation, organ formation, the construction of neural networks, and the learning and memory of the immune system. When a fertilized egg begins its first division, a calcium wave pulls the trigger; when a fetus grows and forms its skeleton, calcium builds the structure; and when nerve cells form their connective network, calcium coordinates synapse formation. Calcium signaling also plays a central role in the process by which immune cells remember and respond to outside invaders.
At this stage calcium works simultaneously like the building material of a construction site and like the radio signal that issues work orders. Cell biology studies explain that "calcium is a highly versatile intracellular signal that operates over a wide temporal range to regulate many different cellular processes." From fast reactions on the scale of milliseconds to the regulation of gene expression over several hours, calcium operates at every time scale.
Conversely, in the collapse stage, as DIAH (Deficiency, Inflammation, Acidosis, Hypoxia) accumulates, calcium leaches out of the bones excessively. When the blood becomes acidified, the body dissolves calcium out of the bones to neutralize it. When there is chronic inflammation, calcium is mobilized to repair the inflamed site. When vitamin D or magnesium is deficient, the absorption and regulation of calcium becomes unstable. In a hypoxic state, cells require more calcium signaling to maintain their normal function.
The calcium that leaks out this way is deposited as calcification throughout the blood vessel walls, heart valves, joints, ligaments, and organs. When it builds up on the vessel wall it becomes arteriosclerosis; when it builds up on a heart valve it becomes valvular stenosis; when it builds up in a joint it worsens degenerative arthritis; and when it builds up in soft tissue it causes pain and functional decline. In this way the 7M mechanisms, namely Obstruction & Rupture, Dysfunction, Coating & Blocking, Hardening, Overflow & Burst, Disconnection, and Collapse, are triggered one after another and slowly bring the structure down.
According to a series of studies by the research team of Professors Demer and Tintut at UCLA, vascular calcification "lowers the flexibility of blood vessels and destabilizes plaque, becoming an underlying factor that greatly raises cardiovascular disease and mortality." When blood vessels calcify they lose their elasticity, blood pressure regulation becomes difficult, and the atherosclerotic plaque becomes unstable so that the risk of rupture rises. This is what leads to myocardial infarction or stroke.
Seen this way, the same substance, calcium, changes its role from the "architect that erects the stage set of evolution" in the growth period to the "demolition specialist that carries out the liquidation of evolution" in the terminal period. That the material that builds life and the material that tears life down are one and the same substance: this is the duality of calcium and the core insight of DIAH-7M. And DIAH-7M is a system that connects the point of transition and the pathway of these two faces and shows them as a single flow.
From Chronic Disease to Evolution, Why It Connects into a Single Line
From the reader's standpoint, there is a moment when one feels most clearly that the DIAH-7M Chronic Disease Pathway System is not mere theoretical play but a frame that runs through both the order of nature and the data of modern medicine at once. It is precisely when this system does not stop at explaining "the beginning and end of disease" but naturally extends even to "the beginning and end of life."
What if we follow the arrows of DIAH-7M backward, up the chain? Let us start from the result called chronic disease. There is hypertension. Why did it arise? Because the vessel wall calcified and lost its elasticity. Why did it calcify? Because calcium that leaked out of the bones was deposited on the vessel wall. Why did the calcium leak out? Because the DIAH triggers, namely deficiency, inflammation, acidosis, and hypoxia, accumulated. Why did DIAH accumulate? Because of the lifestyle habits and environmental stress of modern people.
Up to here we are tracing the causal relationships of chronic disease. But if we take one more step, we arrive at this question. "Why did nature design the life of an individual in this way?" Why is it designed so that once the reproductive period passes, calcium drains out of the bones? Why were we made to become vulnerable to DIAH along with aging? This is an evolutionary question.
And that answer can be found in the theory of evolution. From the standpoint of evolution, the individual is a means of transmitting genes. Once the purpose of reproduction has been achieved, investing in the next generation is more advantageous for gene transmission than investing in maintaining the individual.
So nature designed things to allocate relatively few resources to the maintenance of the individual after the reproductive period. Aging and death are not a design flaw but a design intention.
The message revealed through this journey is simple. It leaves intact the large framework of natural selection that Darwin's theory of evolution spoke of. That framework itself is valid. But as for through what substance that selection is actually executed inside the body, that concrete pathway is precisely calcium, and the map that systematically organizes the flow of that calcium is DIAH-7M.
Seen this way, DIAH-7M is not a theory that denies or replaces the existing theory of evolution. It is an "expanded edition" that gives concrete form, through the substance calcium, to the reality of the execution stage that the theory had not fully resolved. It is like DIAH-7M drawing in the roads and railways on top of the map that Darwin drew. The destination is the same, but how to get there has become clearer.
The Point That It Is Not a "Hypothetical Theory" but a "Map That Rearranges Established Facts"
One of the greatest misunderstandings surrounding DIAH-7M is the perception that it is a completely dogmatic alternative theory that goes its own way, different from existing medicine and evolutionary biology. Some even disparage it as something like "alternative medicine" that runs counter to mainstream medicine. But when you actually look into each and every brick that makes up this system, inside it are neatly stacked facts that have already been validated by the academic world over several decades.
First, the point that intracellular calcium signaling is a universal signaling system used in common by almost all eukaryotic cells is an already established scientific fact. Monumental review papers in the field of cell biology clearly state that "the universality of calcium depends on its enormous versatility. Cells have a calcium signaling toolkit with many components that can be mixed and matched to generate a variety of spatial and temporal signals." These papers have been cited tens of thousands of times and have taken their place as the established view of the field.
Second, the point that bone stores 99% of the body's calcium as a giant reservoir and also serves as a buffering device that regulates the blood calcium concentration belongs to the basics of physiology. It is a fundamental matter taught at every medical school in the world, and it is also confirmed in the official reports of the U.S. National Institutes of Health and the Institute of Medicine.
Third, the point that vascular calcification is an important risk factor that greatly raises cardiovascular disease and mortality has been systematically proven in a series of studies by the Demer and Tintut research team. The coronary artery calcification score is already used as a standard tool for cardiovascular risk assessment.
That the higher the coronary artery calcification score measured by CT, the higher the risk of a cardiovascular event, is a fact confirmed in numerous large-scale studies.
Fourth, the point that chronic inflammation, metabolic acidosis, and hypoxia adversely affect bone health is also a fact that has been independently researched and confirmed in each of these fields. Chronic inflammation activates osteoclasts to promote bone resorption, metabolic acidosis dissolves calcium out of the bones to neutralize the blood, and hypoxia hinders the normal function of bone cells.
What DIAH-7M did was to rearrange these scattered bricks within the frame of "D (Deficiency), I (Inflammation), A (Acidosis), H (Hypoxia)" and the "7M mechanisms." And it redrew that flow from the perspective of "how calcium leaks out of the bones, where it piles up, and in what order it brings the structure down." It connected facts that were already individually known into a single causal flow.
And when this rearrangement was finished, we finally witnessed on this map the scene in which the life cycle of the theory of evolution and the pathway of chronic disease onset naturally connect into a single line. As the individual puzzle pieces fit together, the whole picture was revealed.
It is precisely at this point that DIAH-7M takes on the character of not "a new hypothesis made out of thin air" but "an integrated interpretive frame that reweaves already validated facts by the standard of the order of nature." At its central axis there always lies the execution signal called calcium. DIAH-7M is not so much a new discovery as a new perspective, a new arrangement, a new interpretation.
The Language of Chronic Disease That Reveals the Reality of Evolution
What is interesting is that the various chronic diseases we come to experience as we grow old are in fact a kind of language that reads back "the design intention left by evolution." Chronic disease is not misfortune or coincidence but part of the script that nature wrote.
Consider the way blood vessels harden with calcification. When we are young, blood vessels stretch and contract elastically, responding flexibly to changes in blood pressure. But as we age, calcium builds up on the vessel wall and it hardens. Why does this happen?
It is not simply "because of bad luck." This is the result of nature's cold way of calculating, which after a certain point no longer places the maintenance of that individual as its top priority.
The same goes for calcium piling up in joints and tendons. When we are young, joints move smoothly and tendons stretch elastically. But as we age, calcium is deposited and movement becomes stiff. Frozen shoulder, calcific tendinitis, degenerative arthritis... why do these diseases surge after middle age? Because once the reproductive period passes, nature reduces the resources it invests in maintaining the joints.
That the traces of calcium grow ever more distinct, reaching all the way to the brain and heart, the kidneys and the eyes, is in the same context. Microcalcification builds up in the brain, heart valves thicken with calcification, calcium stones form in the renal tubules, and the lens of the eye develops cataracts. All of this arises from the imbalance of calcium metabolism.
Seen from the perspective of DIAH-7M, all of these diseases are ultimately "a series of procedures in which DIAH is triggered, calcium leaks out of the bones and circulates through the whole body, and the structure is finished off by the 7M mechanisms."
This procedure itself meshes precisely with the flow that the theory of evolution speaks of, "the ending of one individual's life and the clearing of a place for the next generation." Chronic disease is the exit scenario that evolution wrote, and calcium is the actor that executes that scenario.
Then what does it mean for us to understand DIAH-7M, to reduce DIAH in our daily lives, and to manage things so that calcium does not needlessly leak out of the bones? This goes beyond merely avoiding disease. It is "the work of regulating the speed of collapse of the basic blueprint that evolution granted us." We cannot change the timetable that nature has arranged, but we can see it as an attempt to make it gentler up to a certain degree.
To use an analogy, it is like this. A car will one day be scrapped. That is an unavoidable fate. But if you regularly change the oil, care for the tires, and inspect the engine, you can delay the moment of scrapping. In the same way, the human body too will one day end its life. But if you manage DIAH, stabilize calcium metabolism, and delay the triggering of the 7M mechanisms, you can extend your healthy life span.
In this sense, DIAH-7M is a translator that reads out the "reality of evolution" written in the language of chronic disease. At the same time it is also the starting point of a strategy that seeks to extend the healthy life span by turning the execution signal called calcium to our own use in reverse. If you understand the design of evolution, you can find the optimal path within that design.
Conclusion: What We Came to See Through DIAH-7M, the Reality of the Theory of Evolution and the Calcium Execution Pathway
The purpose of this chapter is simple. I hope that you, the reader, will not lightly pass over the DIAH-7M Chronic Disease Pathway System as merely "yet another health theory." Instead, I hope you will feel that, thanks to the reality called calcium and the map called DIAH-7M, we have become able to see one layer deeper into the blank of the execution stage that Darwin's theory of evolution left behind.
The core message we propose can be summarized in the following single sentence. "If Darwin's theory of evolution uncovered the law of natural selection, DIAH-7M revealed how that law is actually executed inside the body, the fact that its execution pathway is implemented through the substance called calcium."
Darwin explained the "why," and DIAH-7M explains the "how." Darwin presented the direction, and DIAH-7M draws the pathway. If Darwin drew the outline of the map, DIAH-7M draws in the roads and railways, the rivers and mountain ranges on top of that map. And at the center of all those pathways flows the substance called calcium.
Now, when you the reader read through the remaining chapters of this book, DIAH-7M will no longer be a vague theory. It will come to you as a vast map that shows how the flow of birth, aging, illness, and death, the intention of evolution, and the execution signal called calcium are all intertwined.
On that map, I hope you will redesign your own life and health strategy anew. I hope this experience, beyond the mere acquisition of information, will lead to a quiet resolve to live a little more in harmony with the order of nature. We cannot go against the design of evolution, but if we understand that design, we can live more wisely. DIAH-7M is the starting point of that understanding.
References
1. Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium. Dietary Reference Intakes for Calcium and Vitamin D. Washington (DC): National Academies Press (US); 2011. https://www.ncbi.nlm.nih.gov/books/NBK56060/
2. Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington (DC): National Academies Press (US); 1997. https://www.ncbi.nlm.nih.gov/books/NBK109827/
3. Carafoli E. Calcium: a universal carrier of biological signals. FEBS J. 2005;272(5):1073-1089. doi:10.1111/j.1742-4658.2005.04546.x https://pubmed.ncbi.nlm.nih.gov/15720383/
4. Berridge MJ, Lipp P, Bootman MD. The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol. 2000;1(1):11-21. doi:10.1038/35036035 https://www.nature.com/articles/35036035
5. Berridge MJ, Bootman MD, Roderick HL. Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol. 2003;4(7):517-529. doi:10.1038/nrm1155 https://www.nature.com/articles/nrm1155
6. Clapham DE. Calcium signaling. Cell. 2007;131(6):1047-1058. doi:10.1016/j.cell.2007.11.028 https://www.cell.com/fulltext/S0092-8674(07)01531-0
7. Brini M, Calì T, Ottolini D, Carafoli E. Intracellular calcium homeostasis and signaling. Met Ions Life Sci. 2013;12:119-168. doi:10.1007/978-94-007-5561-1_5 https://link.springer.com/chapter/10.1007/978-94-007-5561-1_5
8. Demer LL, Tintut Y. Vascular calcification: pathobiology of a multifaceted disease. Circulation. 2008;117(22):2938-2948. doi:10.1161/CIRCULATIONAHA.107.743161 https://pubmed.ncbi.nlm.nih.gov/18519861/
9. Demer LL, Tintut Y. The leading edge of vascular calcification. Trends Cardiovasc Med. 2015;25(4):275-277. doi:10.1016/j.tcm.2014.11.010 https://pubmed.ncbi.nlm.nih.gov/25572012/
10. Tintut Y, Honda H, Demer LL. Biomolecules Orchestrating Cardiovascular Calcification. Biomolecules. 2021;11(10):1482. doi:10.3390/biom11101482 https://pubmed.ncbi.nlm.nih.gov/34680113/
11. Whitaker M. Calcium at fertilization and in early development. Physiol Rev. 2006;86(1):25-88. doi:10.1152/physrev.00023.2005 https://pubmed.ncbi.nlm.nih.gov/16371595/
12. Stricker SA. Comparative biology of calcium signaling during fertilization and egg activation in animals. Dev Biol. 1999;211(2):157-176. doi:10.1006/dbio.1999.9340 https://www.sciencedirect.com/science/article/pii/S0012160699093405
13. Kirkwood TBL. Evolution of ageing. Nature. 1977;270(5635):301-304. doi:10.1038/270301a0 https://www.nature.com/articles/270301a0
14. Kirkwood TBL, Holliday R. The evolution of ageing and longevity. Proc R Soc Lond B Biol Sci. 1979;205(1161):531-546. doi:10.1098/rspb.1979.0083 https://royalsocietypublishing.org/doi/10.1098/rspb.1979.0083
15. Yu E, Sharma S. Physiology, Calcium. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 [updated 2024 Jan 3; cited 2025 Dec 15]. https://www.ncbi.nlm.nih.gov/books/NBK482128/